>>/184146/
Реакция типа этого
https://www.orgsyn.org/demo.aspx?prep=CV4P0281
In a 3-l. round-bottomed flask equipped with a reflux condenser (Note 1) are placed 176 g. (1.60 moles) of diethylamine hydrochloride (Note 2), 68 g. (2.26 moles) of paraformaldehyde, 600 ml. (8.2 moles) of acetone, 80 ml. of methanol, and 0.2 ml. of concentrated hydrochloric acid. The mixture is heated for 12 hours at a moderate to vigorous rate of reflux (Note 3). The light-yellow solution, in which a small amount of gelatinous solid remains, is cooled, and a cold solution of 65 g. of sodium hydroxide in 300 ml. of water is added. The mixture is extracted with three 200-ml. portions of ether, the combined extracts are washed with two 150-ml. portions of saturated sodium chloride solution, and the washes are re-extracted with two 150-ml. portions of ether.
The combined ether solutions are dried overnight with about 80 g. of anhydrous sodium sulfate, filtered, and then distilled under reduced pressure (5 to 12 mm.) (Note 4) through a 20-cm. asbestos-wrapped Vigreux distilling column, with an efficient water-cooled condenser (Note 5). After the solvent and a small fore-run have been distilled, 150–171 g. (66–75%) of 1-diethylamino-3-butanone is collected as a light-yellow to nearly colorless liquid, b.p. 63–67°/7mm. (75–77°/15mm.), n25D 1.4300–1.4310. The product may contain a small amount of 1,1-bis(diethylaminomethyl)acetone (the bis-Mannich base), which can interfere with some uses of this product. Refractionation gives relatively pure material, 142–161 g. (62–70%), b.p. 72–75°/10mm., n25D 1.4301–1.4307, d254 0.8626, MD (found) 43.2–43.3, MD (calcd.) 43.1 (Note 6).