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I believe this depends on the person.
I know people who pack 3 weeks of vacations full of activities and are more tired afterwards, than before they departed on vacation.
And I know people who fly 3 hours to lay on a beach and come back having done literally nothing.
Personally I don't go on vacation. Too much hassle and I don't like hassle. But I'm in the countryside with a large backyard so there's that.