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He needs to have that really good day he has every GT in a big stage. Yates and especially McNulty are fodder, they'll randomly lose 6 minutes at any time. Del Toro is a bit of an unknown, but he hasn't shown anything yet that shows that he can keep up with the main GC for an entire week of high mountains. In one week races he has shown some weakness more than once (though tbf he was never riding as a leader at any of those times). Achooso is the true threat.
If Roglic has the legs, he'll do his thing and fight till the end. If anything, he is no bitch. And more than anyone else, he knows that nothing is over until the final stage (well, stage 20).