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As I said, this is mostly religious question: what is natural and what is not. For example, Christian worldview clearly states that man is different from nature, he has soul, his mind and body are different things etc. From this point of view, humanity surely can do "artifical" and "natural" things.
Eco-worried people often state that they don't adhere to religion, but their worldview is often the same. Although caring about nature doesn't require to differentiate between human and nature, because there are plenty of reasons to care anyway (opposing reasons exist too).