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Cellular Responses to Graphene Oxide Sheets
Very technical presentation so not easy to analyze for a non-specialist. But I think this more or less describes the expt and results.
Graphene Oxide (Go) is associated with potential adverse health effects such as oxidative stress, inflammation and cyto-toxicity
So what are the properties of this material that can lead to injury?
Looked at
- the correlation of cellular responses with the lateral dimensions of the the GO (large vs small)
- the effect of proteins "which can absorb on the surface of these sheets" (which is especially relevant to in vitro conditions)
Manipulated Variables:
- large vs small GOs
- presence or absence of "serum" (has to do with interactions with proteins)
Dependent variables:
- cytotoxicity as measured by cell numbers
- oxidative stress
- inflammatory response
Results:
1. large GOs in large doses more problematic
2. w/serum added: less problematic, especially for small GOs
i don't understand the 'serum added' factor very well, but seems to have a protective effect on cells, especially when the graphene oxide nonparticles are small, not big.