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Kendrick Lamar - DNA
Scotty mar10
Published November 28, 2022 17,702 Views
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Science: A triple helix to cripple viruses
13 April 1991
By Dan Charles
{ snippet }:
A technique to insert a third strand of DNA into the double helix of specific genes could be used to throw a spanner into the works of the cell’s machinery.
The American scientists who developed this triple helix, or triplex, technique hope to eventually cripple viruses in this way.
The same approach could also inhibit the hormone progesterone, and so terminate pregnancies.
Ever since the discovery of the double helix, it has been known that there is room for a third strand of DNA, filling in a groove in the helix,
says Michael Hogan of Baylor College of Medicine in Houston, Texas.
But until recently, there was no way to predict which sequence of nucleotides
– the letters of the genetic alphabet – would form this third strand.
In 1986, Hogan began to investigate ways to design such a third strand.
He founded a company in Houston called Triplex to develop commercial products based on this technology.
Hogan worked from the exact sequence of a target gene, and deduced rules for designing a single strand of nucleic acids that would bind to that gene.
He then synthesised a strand, generally only 25 to 35 nucleotides long. Such short pieces of DNA are readily assimilated into the cell’s nucleus,
where they attach to the gene.
At places where this third strand attaches, forming a triple helix, genes are prevented from functioning normally.
Proteins known as ‘transcription factors’, which normally bind to the double helix and switch on specific genes, cannot gain a foothold on the triple helix.
https://www.newscientist.com/article/mg13017644-100-science-a-triple-helix-to-cripple-viruses/
https://archive.ph/6yYJ7
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