Johnson and Johnson announced, that their adenovector based HIV vaccine "was not effective in preventing HIV infection"
https://www.jnj.com/janssen-and-global-partners-to-discontinue-phase-3-mosaico-hiv-vaccine-clinical-trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529856/
@USMortality
Despite the vaccine leading to successful antibody production in all test subjects, infections were not prevented.
We have essentially seen the same with the SARS-CoV-2 studies, where the manufacturers already seem to have known, that they wouldn't stop infection, hence they did not even define it as a study endpoint.
This begs the question, if antibodies are truly ever able to stop infections?