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But interestingly, N-methoxyacetamide fentanyls are even stronger in activity than propanamide ones?
>> bb/137746@135133
> Borohydride replaced with electrolysis of dull
How do you imagine that? Electrolysis in what solution? In water, there'll be hydrolysis of imine. In alcohol, you don't know what.
>> bb/137745@135133
>> When dikman cyclization, 1 carbon is decarboxylated
Draw how you see it. Did you take 2.5 instead of 3.5? I have just sketched out the mechanism, but I hope it will be clear: with two methyl methacrylates, this ether is obtained, which cyclizes (if this reaction goes at all) and decarboxylates in acid, giving 3.5-dimethyl ketone for the fent. Right?